Journal article
Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue
STF Hsiao, A Asgari, Z Lokmic, R Sinclair, GJ Dusting, SY Lim, RJ Dilley
Stem Cells and Development | Published : 2012
Abstract
Human adult mesenchymal stem cells (MSCs) support the engineering of functional tissue constructs by secreting angiogenic and cytoprotective factors, which act in a paracrine fashion to influence cell survival and vascularization. MSCs have been isolated from many different tissue sources, but little is known about how paracrine factor secretion varies between different MSC populations. We evaluated paracrine factor expression patterns in MSCs isolated from adipose tissue (ASCs), bone marrow (BMSCs), and dermal tissues [dermal sheath cells (DSCs) and dermal papilla cells (DPCs)]. Specifically, mRNA expression analysis identified insulin-like growth factor-1 (IGF-1), vascular endothelial grow..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to acknowledge support from the National Health and Medical Research Council for project grant (No. 509271), scholarship to S. H. (No. 567152) and A. A. (No. 567168), and fellowship to G. D. (No. 1003113). R. S. would like to acknowledge the support of Skin & Cancer Foundation of Victoria. The O'Brien Institute acknowledges the support of JO and JR Wicking Trust, Cass Foundation and Victorian State Government's Department of Innovation, Industry and Regional Development's Operational Infrastructure Support Program. We thank Mr. Keith Mutimer and Dr. Russel Knudsen for providing specimens. The authors would also like to acknowledge Dr. Keren Abberton for her critical review of the manuscript.